Golden Gene Chips

A team of chemists and physicists used nanotechnology and DNA's ability to self-assemble with matching RNA to create a new kind of chip for measuring gene activity. When RNA of a gene of interest binds to a DNA tile (gold squares), it creates a raised surface (white areas) that can be detected by a powerful microscope. This nanochip approach offers manufacturing and usage advantages over existing gene chips and is a key step toward detecting gene activity in a single cell. Courtesy of nanotechnologist Hao Yan and Ph.D. candidate Yonggang Ke, Arizona State University.

Featured in the February 20, 2008, issue of Biomedical Beat.
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