Structural Biologist Mavis Agbandje-McKenna:
Closes in on Viruses
Range from harmless to deadly
Can change from harmless to deadly
Need carbohydrates to enter cells
What is another name for carbohydrates?
Structural biologist Agbandje-McKenna
wants to solve the mysteries of how
viruses hop from one host to another.
Carbohydrates: essential for many biological processes
Most cells have carbohydrates (glycans) on their outer surfaces
Influenza A virus infects cells by attaching to glycans on host cells
Outer layer (capsid protein) of MVM resembles 20-sided soccer ball
MVM capsid protein contains cavity it uses to recognize and bind specific glycans
3-dimensional crystal structure showing surface of usually mild strain of minute virus of mice (MVMp)
Unraveling Viral Mysteries Step-By-Step
Solving Viral Mystery #1
Solving Viral Mystery #2
Poultry, People, and a Possible Pandemic
Glycobiology and Pandemics
In what ways might Agbandje-McKenna's research about how viruses infect cells be applied to help patients with cancer?