Solving Viral Mystery #1

Solving Viral Mystery #1

Long Description: • Observation: MVMp-infected mice are suddenly dying. • Research question: What made MVMp become deadly? • Hypothesis: Genetic change created mutant capsid protein. • Investigation: Decode genetic sequence of deadly MVMp and compare with normal MVMp genetic sequence. • Known facts: Both strains of MVM are molecularly similar but have alterations in 14 of 587 amino acids that make up the virus' protective capsid protein shell. • Discoveries: 3 mutations, each causing a unique change in 1 amino acid in the capsid protein.

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