Solving Viral Mystery #2

Steps to Solving Viral Mystery #2

Long Description: • Observation: Mutated MVMp has 1 amino acid that differs from normal MVMp. • Research question: What makes the mutation deadly? • Hypothesis: Change is located in critical region of capsid shell. • Investigation: Develop 3-D structure of MVM to identify locations of 3 mutant amino acids. • Known facts: MVM capsid protein contains a cavity it uses to recognize and bind specific glycans so that the virus can enter and infect cells. • Discoveries: At least 2 changed amino acids sit inside the capsid shell cavity.

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