Building Knowledge

  • Problem: DNA in T7 bacteriophage is a program that needs to be decoded

  • Typical approach: Pry apart genome to investigate the function of each gene

  • Endy's approach: Use genome's parts to construct a synthetic, model genome of T7 bacteriophage that includes not only viral genes but also "cut-and-paste" sites in its DNA

Investigate genes one-by-one

Build genome from scratch, then study how whole thing works

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