Findings: Otto's Rabbit Experiment
Oxygen levels fluctuated wildly in the ventilated, anesthetized rabbit.
The alveoli snapped open and closed with each pump of the ventilator.
The breathing machine could not maintain the inflated, semi-full structure typical of alveoli in healthy animals or people.
The continual stress of expanding and deflating alveoli appears to wear them out.
Ventilators may damage lungs by eroding their cellular fabric.