Haywire Immune Response:
NO Way Out Hypothesis

Image: Process of Haywire Immune Response

Long Description: (1) Injury or infection occurs (2) Immune system deploys immune cells called macrophages (3) Microscopic blood clots form, leading to hypoxia (reduced blood flow, low oxygen) (4) Macrophages increase production of inducible nitric oxide synthase (iNOS), the enzyme that makes NO (5) iNOS builds up inside macrophages (6) Amassed iNOS unleashes destructive flood of NO that causes widespread inflammation

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