PSI-2 Large-scale Centers Target selection

• Dramatically increase the number of families with known structures

• Increase unique structures to ~8,000

• Increase structural coverage of sequenced genes

• Concentrate on large sequence families

• Increase structural information on sequenced genes to 70%

• Consider biological impact

• Requires 8,000 to 10,000 unique experimental structures

NIGMS Protein Structure Initiative

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