Nuclear Gatekeepers

After 9 years of intense effort, a collaborative research team has succeeded in dissecting the structure of the nuclear pore complex (NPC), an assembly of 456 proteins that controls the flow of molecules between the DNA-storing nucleus and the rest of the cell. This video highlights 30 different types of proteins found in the donut-shaped complex from yeast. The work—led by Andrej Sali of the University of California, San Francisco, and Michael P. Rout and Brian Chait of Rockefeller University—may shed light on the function and evolution of the NPC and other large protein assemblies. Video featured with permission from Macmillan Publishers Ltd: Nature 450:695-701, 2007.

Featured in the January 16, 2008, issue of Biomedical Beat.
High res. image (240 KB JPG)