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Science Education: Structural Biology

Protein structuresUnderstanding the shapes of biological molecules to learn more about how they function and interact—that's structural biology. Studies in structural biology focus on questions like:

  • Why does a protein's shape matter?
  • How can misshapen molecules make us sick?
  • How can we visualize the structural details of large and complex molecules?

Follow the links below to learn more about structural biology,including recent developments, and read profiles of researchers working in this field.


Cover image of The Structures of LifeThe Structures of Life
Reveals how structural biology provides insight into health and disease and is useful in developing new medications.

Cover image of Computing LifeComputing Structural Biology from Computing Life
Shows how combining chemistry and computers helps scientists understand and predict how proteins fold and interact and could lead to new medicines for protein-related disorders.

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Fact Sheet

Helices (red) and beta sheets (blue) make up this protein. Credit: RCSB Protein Data BankStructural Biology
Structural biology is a field of science focused on understanding the shapes of biological molecules. Learn about why and how scientists study these structures.

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Science Highlights

Protein Alphabet: A Picture Is Worth One Letter
A biochemist from Oxford pored over thousands of protein structures from the Protein Data Bank to find these 26 protein crystal structures that resemble letters of the alphabet.

Researchers Score Goal with New Atomic-Scale Model of Salmonella-Infecting Virus
Researchers used new computational methods to construct a soccer-ball looking virus model from more than 20,000 cryo-electron microscopy (cryo-EM) images.

HIV capsid with (left, red) and without (right) a camouflaging human protein.Viral Views: New Insights on Infection Strategies
Cutting-edge research tools are giving us clearer views of viruses—and possible ways to disarm them.

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Profiles: Meet a Scientist

George HightowerHIV on the Brain
Graduate student George Hightower researches genetic mutations that affect HIV's ability to infect the brain.

David BakerThe Family Business
Computational biologist David Baker custom designs computer software to predict the three-dimensional shapes of proteins.

Mavis Agbandje-McKennaViral Voyages
Structural biologist Mavis Agbandje-McKenna studies how viruses infect cells.

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Audio and Video

Structure of a pair of linked CXCR4 molecules (blue and gold) bound by loop-shaped peptide inhibitors (red and magenta). Courtesy of Raymond C. Stevens, the Scripps Research Institute, La Jolla, Calif.Modeling How HIV Latches on to Immune Cell Receptors
This model shows how HIV, in gray, might latch on to immune cell receptor molecules, allowing the virus to enter and infect the cell.

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Interactive TimelineInteractive Timeline - 50 Years of Protein Structure Determination
A timeline of significant research advances in protein structure determination.

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Quizzes and Puzzles

Proteins Professor Cartoon Test Your Science IQ! Game: Proteins
HTML Versions: High School Level | College Level | Graduate Level
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The Structures of Life crosswordThe Structures of Life Crossword Puzzle | Accessible Version

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This page last reviewed on August 30, 2017