Science Education: Structural Biology
Understanding the shapes of biological molecules to learn more about how they function and interact—that's structural biology. Studies in structural biology focus on questions like:
- Why does a protein's shape matter?
- How can misshapen molecules make us sick?
- How can we visualize the structural details of large and complex molecules?
Follow the links below to learn more about structural biology,including recent developments, and read profiles of researchers working in this field.
The Structures of Life
Reveals how structural biology provides insight into health and disease and is useful in developing new medications.
Computing Structural Biology from Computing Life
Shows how combining chemistry and computers helps scientists understand and predict how proteins fold and interact and could lead to new medicines for protein-related disorders.
Structural biology is a field of science focused on understanding the shapes of biological molecules. Learn about why and how scientists study these structures.
Cryo-Electron Microscopy Reveals Molecules in Ever Greater Detail
The journal Nature Methods named cryo-EM the “2015 Method of the Year.” Here are a couple examples of how scientists have used this technology to bring biological structures into unprecedented focus.
Seeing Telomerase's 'Whiskers' and 'Toes'
Like the features of a cat in a dark alley, those of an enzyme that plays a critical role in health and disease have been elusive-until now.
Unusual DNA Form May Help Virus Withstand Extreme Conditions
Storing genetic information in an unusual DNA form may help a heat-loving organism survive brutal conditions.
HIV on the Brain
Graduate student George Hightower researches genetic mutations that affect HIV's ability to infect the brain.
The Family Business
Computational biologist David Baker custom designs computer software to predict the three-dimensional shapes of proteins.
Structural biologist Mavis Agbandje-McKenna studies how viruses infect cells.
Cool Video: HIV's Inner Shell
Scientists have determined the exact structure of the inner shell of HIV, which contains its genetic material. This finding may lead to new and more effective HIV antiretroviral drugs.
Cool Video: How a Virus Infects
Watching how a T7 virus changes its structure to infect a cell could shed light on how other viruses infect as well as aid the design of new drugs.
Modeling How HIV Latches on to Immune Cell Receptors
This model shows how HIV, in gray, might latch on to immune cell receptor molecules, allowing the virus to enter and infect the cell.
Cool Image: Making the Ribosome Move
Details gleaned from this atomic-resolution image of the protein-building ribosome bound to the molecule that controls its motion could lead to better antibiotics.
Interactive Timeline - 50 Years of Protein Structure Determination
A timeline of significant research advances in protein structure determination.
Cool Image: Exploring HIV
Structures related to HIV have helped paint this detailed picture of the virus and have led to some important classes of drugs to treat the infection.