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Contacts by Research Area

Biomedical Technology, Bioinformatics, and Computational Biology

Cell Biology and Biophysics

Genetics and Developmental Biology

Pharmacology, Physiology, and Biological Chemistry

Research Capacity Building

Training, Workforce Development, and Diversity


Biomedical Technology, Bioinformatics, and Computational Biology

Bioinformatics and Computational Biology

Bioinformatics, Computational Biology and Modeling

Bioinformatics applications in the general area of complex biological systems to create or maintain databases, develop or use methods to manage, visualize and analyze data in these databases or use methods commonly associated with bioinformatics to deduce information about biological systems. Excludes applications related to structural genomics, protein structure and population biology. Computational biology applications should develop new approaches, algorithms and methods for an integrative understanding of biomedical systems and could span temporal and spatial domains.

Paul Brazhnik, Ph.D. (Bioinformatics and Computational Biology)
Tel: 301-451-6446
E-mail: brazhnikp@nigms.nih.gov
Biographical sketch

Veerasamy Ravichandran (Bioinformatics and Modeling)
Tel: 301-451-6446
E-mail: veerasamy.ravichandran@nih.gov
Biographical sketch

Biostatistics

Biostatics areas of interest include developing the methods and theories necessary for improving quantitative measures of biological and behavioral processes.

Paul Brazhnik, Ph.D.
Tel: 301-451-6446
E-mail: brazhnikp@nigms.nih.gov
Biographical sketch

Stephen Marcus
Tel: 301-451-6446
E-mail: stephen.marcus@nih.gov
Biographical sketch

Centers -- Complex Biological Systems Not Related to Trauma and Burn

Paul Brazhnik, Ph.D.
Tel: 301-451-6446
E-mail: brazhnikp@nigms.nih.gov
Biographical sketch

Sarah E. Dunsmore, Ph.D.
Tel: 301-594-3827
E-mail: dunsmores@nigms.nih.gov
Biographical sketch

Centers -- Complex Biological Systems Related to Trauma and Burn

Scott D. Somers, Ph.D.
Tel: 301-594-3827
E-mail: somerss@nigms.nih.gov
Biographical sketch

Biomedical Technology

Biomedical Technology Research Resources (BTRRs)

These resources create critical, often unique technology and methods at the forefront of their respective fields and apply them to a broad range of basic, translational and clinical research. This occurs through a synergistic interaction of technical and biomedical expertise, both within the centers and in intensive collaborations with other leading laboratories.

Doug Sheeley, Sc.D.
Tel: 301-451-6446
E-mail: sheeleyd@mail.nih.gov
Biographical sketch

Investigator-Initiated Research Grants

These grants support technology-driven, investigator-initiated research. Projects funded under these grants could lead to new or improved instruments, technologies, devices and methodologies that will have broad application to biomedical research.

Doug Sheeley, Sc.D.
Tel: 301-451-6446
E-mail: sheeleyd@mail.nih.gov
Biographical sketch

Small Business Grants

The biomedical technology program seeks to increase small business participation in federally supported research and development as well as the private-sector commercialization of technology developed with federal support.

Mary Ann Wu, Ph.D.
Tel: 301-451-6446
E-mail: wum2@mail.nih.gov
Biographical sketch

Cell Biology and Biophysics

Biophysics

Biophysical Properties of Nucleic Acids

Research involving the application of physical principles to the study of nucleic acids and protein-nucleic acid complexes. Areas of research include: physical and chemical studies on the structure of nucleic acids and protein-nucleic acid complexes; analysis of protein-nucleic acid interactions and assembly mechanisms; ligand-nucleic acid interactions; development of physical, chemical and theoretical/computational techniques for the analysis of nucleic acids and their complexes.

Peter C. Preusch, Ph.D.
Tel: 301-594-0828
E-mail: preuschp@nigms.nih.gov
Biographical sketch

Biophysical Properties of Proteins

Biophysical studies of protein structure and stability in which the goal is to elucidate general principles. Physical and thermodynamic basis for native structure, protein-protein interactions and protein-ligand recognition. De novo protein design and engineering.

Ward Smith, Ph.D.
Tel: 301-594-0828
E-mail: smithwar@nigms.nih.gov
Biographical sketch

Cell and Structural Biology of the Viral Life Cycle

Research involving the application of physical principles to the study of viral attachment, fusion/penetration, uncoating, assembly and budding/release. Areas of research include: analysis of virus-host interactions; phage and viral packaging; the structure and mechanism of assemblies from viral and host components; and the determination of factors and energetics that regulate protein-nucleic acid interactions necessary for virion entry, packaging, maturation and release.

Michael Sakalian, Ph.D.
Tel: 301-594-0828
E-mail: sakalianm@nigms.nih.gov
Biographical sketch

Diffraction Analysis of Biological Macromolecules

Structural studies of protein and macromolecular assemblies utilizing X-ray crystallography and related methods. Emphasis is on analysis of complex or technically difficult structures. Development of new or improved methods for diffraction analysis such as instrumentation, experimental techniques and data analysis. Development of better methods for crystallization.

Paula Flicker, Ph.D.
Tel: 301-594-0828
E-mail: flickerp@nigms.nih.gov
Biographical sketch

Nuclear Magnetic Resonance Analysis of Biological Macromolecules

Studies of proteins, nucleic acids, peptides and related biological macromolecules where the emphasis is on the use of nuclear magnetic resonance; development of techniques for nuclear magnetic resonance spectroscopy.

Janna Wehrle, Ph.D.
Tel: 301-594-0828
E-mail: wehrlej@nigms.nih.gov
Biographical sketch

Protein Folding and Dynamics

Studies of protein folding, in vivo and in vitro, in which the goal is to elucidate general principles. Protein folding mechanisms and kinetics. The role of molecular chaperones in facilitating folding. The role of structural mobility in protein function, folding and allosteric control.

Janna Wehrle, Ph.D.
Tel: 301-594-0828
E-mail: wehrlej@nigms.nih.gov
Biographical sketch

Proteomics Research

Studies of basic biology and biochemistry within the general sphere of interest of the Institute which is based on genomic data combined with information on the complete complement of proteins present in the system under investigation.

Charles Edmonds, Ph.D.
Tel: 301-594-0828
E-mail: edmondsc@nigms.nih.gov

SBIR/STTR Program in Cell Biology and Biophysics

This portfolio comprises SBIR/STTR projects of general interest to the Division of Cell Biology and Biophysics but that are not distributed to other program directors and portfolios within the division on the basis of their specific scientific relevance. These projects are notable for their general pertinence to basic science issues and broad applicability of the proposed developments.

Charles Edmonds, Ph.D.
Tel: 301-594-0828
E-mail: edmondsc@nigms.nih.gov

Single Molecule Biophysics and Nanoscience

Research on, and development of, new and improved instruments, methods and technologies for nanoscience, and for the analysis of single protein and nucleic acid molecules and their complexes in vivo and in vitro. Current approaches include optical and fluorescent spectroscopies, scanning probe microscopy and biomechanical techniques to analyze the behavior and heterogeneity of single molecules and subcellular structures at the nanometer scale. Examples of targets for study include protein or RNA folding, enzyme catalysis, signaling, molecular machines and the assembly and dynamics of complex cellular structures. A major goal is to develop and enhance existing methods and reagents for the 3-D visualization of cellular processes in living cells in real time at high resolution.

Charles Edmonds , Ph.D.
Tel: 301-594-0828
E-mail: edmondsc@nigms.nih.gov

Structure-Based Drug Design Related to AIDS

Interdisciplinary program projects, involving structural biologists, synthetic organic chemists, theoreticians and virologists whose purpose is to develop anti-AIDS drugs using structure-based drug design.

Michael Sakalian, Ph.D.
Tel: 301-594-0828
E-mail: sakalianm@nigms.nih.gov
Biographical sketch

Theoretical Studies of Protein Folding, Association and Aggregation

Includes theoretical and computationally based studies on protein folding pathways and mechanisms leading both native and non-native protein conformational states, protein-protein associations leading to protein aggregates and precipitates (e.g., amyloid formation), and protein-protein complex formation leading to supramolecular complexes. Includes prediction of protein structures from sequence, homology modeling based on known protein structures, recognition of protein folds.

Janna Wehrle, Ph.D.
Tel: 301-594-0828
E-mail: wehrlej@nigms.nih.gov
Biographical sketch

Theoretical Studies of Protein-Ligand Interactions

Includes theoretical and computationally based studies on the basic molecular forces and effects that drive molecular interactions (electrostatics, hydrogen bonding hydration effects), applications of these forces to the docking of small molecules with proteins (including studies of protein and ligand conformational dynamics), and details of the active site interactions as examined by quantum mechanics, molecular dynamics and related methods. Non-AIDS-related structure-based drug design.

Peter C. Preusch, Ph.D.
Tel: 301-594-0828
E-mail: preuschp@nigms.nih.gov
Biographical sketch


Cell Biology

Cell Attachment, Extracellular Matrix and Signaling

Molecular biology and cell biology of cell attachment and the extracellular matrix (ECM). The structural biology of related signaling processes. Cell surface proteins mediating cell-cell and cell-matrix interactions. Composition, structure, assembly, remodeling and function of the ECM. Structural biology of signaling associated with cell attachment, chemokines, receptor protein kinases and adapter proteins.

Paula Flicker, Ph.D.
Tel: 301-594-0828
E-mail: flickerp@nigms.nih.gov
Biographical sketch

Cell Organization, Motility and Division

Spatial organization in cells, nonmuscle motility and the regulation of cell division. Structure and function of the cytoskeleton. Molecular motors, mechanisms of motility and chemotaxis. Structural and dynamic aspects of mitosis and meiosis, spindle structure and assembly, chromosome attachment and movement.

James F. Deatherage, Ph.D.
Tel: 301-594-0828
E-mail: deatherj@nigms.nih.gov

Membrane Structure, Transport and Lipid Metabolism

All aspects of membrane structure including the nature of bilayers, membrane protein-lipid interactions and membrane transport. The cell biology and biophysics of membrane lipids, lipid structure and function, lipid interactions and lipid and membrane mediators of signal transduction.

Alexandra Ainsztein, Ph.D.
Tel: 301-594-0828
E-mail: ainsztea@nigms.nih.gov
Biographical sketch

Membrane Synthesis and Function

All aspects of membrane synthesis including membrane development and maintenance. Function includes membrane turnover, passive transport, membrane receptors, endocytosis, protein targeting.

Alexandra Ainsztein, Ph.D.
Tel: 301-594-0828
E-mail: ainsztea@nigms.nih.gov
Biographical sketch

Joe Gindhart, Ph.D.
Tel: 301-594-0828
E-mail: gindhartjg@nigms.nih.gov
Biographical sketch

Membrane Trafficking

Research focused on the molecular mechanisms and dynamics of the secretory pathway, and organelle biogenesis. Areas include membrane translocation; regulation of vesicle-mediated trafficking; intracellular protein processing and targeting; and organelle inheritance, motility and function.

Alexandra Ainsztein, Ph.D.
Tel: 301-594-0828
E-mail: ainsztea@nigms.nih.gov
Biographical sketch

Microscopy of Molecules and Cells

Analysis of the structures of cells, supramolecular assemblies and macromolecules by microscopy. Applications and technology development of microscopy at the atomic through cellular levels. High-resolution electron microscopy, cellular tomography, light microscopy (including three-dimensional methods), X-ray microscopy, scanning probe microscopy and other microscopic methods for visualizing cellular and molecular structure. Development of reagents, instrumentation and software related to the above for basic research on cellular and molecular structure and function.

James F. Deatherage, Ph.D.
Tel: 301-594-0828
E-mail: deatherj@nigms.nih.gov

Paula Flicker, Ph.D.
Tel: 301-594-0828
E-mail: flickerp@nigms.nih.gov
Biographical sketch

Motors, Filaments and Transport

Cytoskeletal filaments and their interactions with molecular motors. Organization and dynamics of the cytoskeleton during mitosis, meiosis and cytokinesis. Structure, function and assembly of cilia and flagella. Establishment and maintenance of cell polarity. Organelle organization and transport within cells. Bacterial motility.

Joe Gindhart, Ph.D.
Tel: 301-594-0828
E-mail: gindhartjg@nigms.nih.gov
Biographical sketch


Genetics and Developmental Biology

Developmental and Cellular Processes

Cell Cycle

Control of cell cycle progression: areas include genetic and molecular regulation and function of cell cycle checkpoints and components of the cell cycle, such as cyclins, cyclin-dependent kinases (CDKs), inhibitors, activators and tumor suppressors; synthesis, post-translational modification and degradation of the cell cycle machinery, including ubiquitination and sumoylation; temporal and spatial regulation of the cell cycle.

Amanda Melillo, Ph.D.
Tel: 301-594-0943
E-mail: amanda.melillo@nih.gov
Biographical sketch

Cell Death, Autophagy and Homeostasis

Focuses on the regulation of cellular homeostasis, autophagy and cell death pathways. Emphasis is on principles determining intracellular signaling pathway dynamics and network organization. Areas include metabolic and protein homeostasis, induction and regulation of macroautophagy, programmed cell death, apoptosis and alternative cell death pathways.

Stefan Maas, Ph.D.
Tel: 301-594-0943
E-mail: maassw@nigms.nih.gov
Biographical sketch

Cell Growth and Differentiation

Focuses on cellular decision processes, e.g., growth initiation, proliferation, cell senescence, terminal differentiation, sporulation and chemotaxis regulation. Emphasis is on principles determining intracellular signaling pathway dynamics and network organization. Approaches may include genomics, proteomics or computational modeling, where such models are focused on signaling networks.

Amanda Melillo, Ph.D.
Tel: 301-594-0943
E-mail: amanda.melillo@nih.gov
Biographical sketch

Chromosome and Nuclear Structures

The principal areas of focus are higher order chromosome architecture, telomeres, centromeres, specialized nuclear substructures, boundary elements, long distance regulators, and spatial organization of genes. Research topics include: structure/function of telomerase, maintenance of telomere length, noncoding RNA effects on telomerase, centromere structure and identity, centromere assembly, and large scale programmed genome rearrangements.

Anthony Carter, Ph.D.
Tel: 301-594-0943
E-mail: cartera@nigms.nih.gov
Biographical sketch

Chromosomes and Epigenetics

Identification and characterization of structural and functional components of gene activation and repression. Areas include structure and function of chromatin and large protein-DNA complexes, including interactions of DNA with nonhistone proteins; epigenetic factors influencing gene expression such as histone modifications, chromatin remodeling, DNA methylation, heterochromatin formation, position effects, imprinting, X-inactivation, gene silencing.

Anthony Carter, Ph.D.
Tel: 301-594-0943
E-mail: cartera@nigms.nih.gov
Biographical sketch

Developmental Genetics

Regulation of early development in multicellular organisms, with an emphasis on non-mammalian systems. Areas include but are not limited to: genetic and molecular regulation of embryonic pattern formation, tissue induction, cell fate determination, and cell and tissue polarity; spatial and temporal localization of developmental determinants; regulation of cell movements in embryogenesis, including early morphogenesis (including biophysical/biomechanical forces); gene regulatory networks controlling developmental pathways; sex determination.

Tanya Hoodbhoy, Ph.D.
Tel: 301-594-0943
E-mail: tanyah@mail.nih.gov
Biographical sketch

Developmental Signaling

Investigations whose major emphasis is on understanding signaling pathways underlying fundamental processes that drive early (pre-organogenesis) development, primarily using non-mammalian systems. Research should be predominantly focused on the signaling cascades involved in developmental patterning and morphogenetic events rather than on gene regulatory networks or biophysical/biomechanical and cell-level mechanisms. Topics include but are not limited to growth factor/morphogen signaling networks, planar cell polarity signaling, cytoneme/airineme-based signaling, and signaling during collective cell migration.

Kenneth Gibbs, Ph.D.
Tel: 301-594-3901
E-mail: kenneth.gibbs@nih.gov
Biographical sketch

Ethical, Legal and Social Issues in Genetics

Ethical, legal and social issues in genetics, especially as they relate to the use of stored human tissues for research and to studies on ethnically identifiable populations.

Donna Krasnewich, M.D., Ph.D.
Tel: 301-594-0943
E-mail: dkras@nigms.nih.gov
Biographical sketch

Neurogenetics and the Genetics of Behavior

Genetic, molecular and/or genomic characterization of simple and complex behaviors in nonhuman model systems, where the focus is on neural function rather than neural development. Genetic, molecular and/or genomic characterization of circadian rhythms, sleep and related phenomena in nonhuman systems, with an emphasis on invertebrates, plants, fungi and bacteria.

Michael Sesma, Ph.D.
Tel: 301-594-0943
E-mail: msesma@nigms.nih.gov
Biographical sketch

Organismal Response to the Environment and Microbe-Host Interactions

Investigations into the regulatory pathways that control expression of protective genes in response to growth-limiting stressors (such as antibiotics, oxygen levels, temperature, pH, light, gravity, parasitism, toxins and metal ions). Approaches range from molecular and chemical analysis to theoretical model development. Elucidation of genetic, physiological and ecological mechanisms governing interchanges between dissimilar organisms, such as commensal, mutualistic, parasitic and symbiotic relationships. The manner by which the microbiota, including biofilms, respond - either at the community, population, organismal or molecular level - to maintain homeostasis or respond to dysbiosis of the host.

Michael Reddy, Ph.D.
Tel: 301-594-0943
E-mail: reddymk@nigms.nih.gov
Biographical sketch

Stem Cell Biology and Regeneration

Studies on the fundamental properties of adult, germline and embryonic stem cells and on the regulation of tissue and organ regeneration. Stem cell areas include: molecular, cellular, genetic and epigenetic properties of stem cells; nuclear reprogramming of somatic cells, including induced pluripotent stem cells (iPS); signaling pathways in stem cell differentiation; role of stem cell niches and microenvironments in stem cell differentiation; germ cell formation and development. Regeneration areas include genetic, molecular and/or genomic regulation of tissue and organ regeneration in nonhuman model systems, including plants.

Susan Haynes, Ph.D.
Tel: 301-594-0943
E-mail: hayness@nigms.nih.gov
Biographical sketch


Genetic Mechanisms

DNA Repair and Mutagenesis

Enzymes and mechanisms of DNA repair; mechanisms of action of mutagens and carcinogens; genetics and biochemistry of mutation; interactions of mutagens with nucleic acids.

Kristine Willis, Ph.D.
Tel: 301-594-0943
E-mail: kristine.willis@nih.gov
Biographical sketch

DNA Replication

Enzymes and mechanisms of DNA and RNA replication; chromatin regulation of DNA replication; genetics of meiosis; role of recombination in replication; and evolutionary analyses of replication pathways.

Michael Reddy, Ph.D.
Tel: 301-594-0943
E-mail: reddymk@nigms.nih.gov
Biographical sketch

Genetic Basis of Human Biology

Investigations of genetic mechanisms in humans that determine phenotypes evaluated at the molecular, biochemical, cellular or clinical level; genetic studies employing eukaryotic model organisms relevant to a human genetic disorder or phenotype; genetic and environmental factors that influence common disorders with complex inheritance; computational and statistical approaches to the analysis of genetic variation influencing human phenotypes; development of genetic and genomic techniques specific to investigations of human material.

Donna Krasnewich, M.D., Ph.D.
Tel: 301-594-0943
E-mail: dkras@nigms.nih.gov
Biographical sketch

mRNA Metabolism and Translational Control

Structure, function and metabolism of cytoplasmic mRNA. Control of gene expression at the level of translation, including RNA editing, mRNA stability, and nonsense-mediated decay.

Michael Bender, Ph.D.
Tel: 301-594-0943
E-mail: mbender@nigms.nih.gov
Biographical sketch

Population Genetics and Evolution

Genetics of natural and laboratory populations; analysis of genetic variation in complex traits in humans and model organisms; evolutionary principles of living systems, including chromosome evolution, phenotypic evolution and speciation; evolution of development; co-adapting systems such as host-pathogen evolution; statistical methods and mathematical models for evolutionary and population genetic analysis.

Daniel Janes, Ph.D.
Tel: 301-594-0943
E-mail: janesde@nigms.nih.gov
Biographical sketch

Protein Synthesis

Protein synthesis as a process, including initiation, elongation and termination; synthesis, structure and function of all biochemical components of the translation system, namely tRNA, rRNA, ribosomal proteins and initiation and termination factors.

Michael Bender, Ph.D.
Tel: 301-594-0943
E-mail: mbender@nigms.nih.gov
Biographical sketch

Regulatory RNAs

Mechanisms of production and regulation of regulatory RNAs including siRNAs, microRNAs, piRNAs, CRISPR RNAs and related non-coding RNAs. Function of regulatory RNA including effects on mRNA stability or translation.

Michael Bender, Ph.D.
Tel: 301-594-0943
E-mail: mbender@nigms.nih.gov
Biographical sketch

RNA Processing

Splicing of all species of RNA following completion of transcription and prior to translational events in the cytoplasm; processing of RNA, including methylation, capping and polyadenylation; mechanism and regulation of alternative splicing and trans-splicing; formation, structure, function and regulation of spliceosomal precursors and components; mechanism and regulation of self-splicing; intranuclear transport of RNA.

Michael Bender, Ph.D.
Tel: 301-594-0943
E-mail: mbender@nigms.nih.gov
Biographical sketch

Transcription Mechanisms

Genetic, biochemical, biophysical and structural characterization of the macromolecular interactions that mediate DNA-dependent RNA transcription; genomics- and expression-based strategies for identifying, on a global basis, molecules and sequences involved in regulating transcription; development of reagents and techniques for visualizing or manipulating transcription.

Darren Sledjeski, Ph.D.
Tel: 301-594-0943
E-mail: darren.sledjeski@nih.gov
Biographical sketch

Pharmacology, Physiology, and Biological Chemistry

Biochemistry and Biorelated Chemistry

Bioenergetics and Mitochondrial Physiology

The topics include: 1) structure, mechanisms, assembly and regulation of the substrate transporters and energy-transducing enzymes of the mitochondrial inner and outer membranes, chloroplasts and microorganisms--electron transport, photosynthesis, H+-coupled ATPases, including vacuolar and outer membrane H+-ATPases; 2) related metabolism, including biogenesis of cofactors and substrate transport; 3) metabolic diseases arising from mitochondrial dysfunction.

Vernon Anderson, Ph.D.
Tel: 301-594-3827
E-mail: andersonve@nigms.nih.gov
Biographical sketch

Bioinorganic Chemistry

Studies of the structural and functional role of metal ions in biological systems, particularly those of metalloenzyme structure and function, mechanisms of action and inhibition. The design and preparation of structural/functional models of metal sites in proteins and comparisons of those models with the native proteins. Metal ion homeostasis, including pathways of cellular uptake and subcellular transport, sensors of metal ion concentrations and the role of metals as sensors and effectors in regulation of metabolism. Interactions of metal ions and metal-containing drugs with nucleic acids.

Miles A. Fabian, Ph.D.
Tel: 301-594-3827
E-mail: fabianm@nigms.nih.gov
Biographical sketch

Vernon Anderson, Ph.D.
Tel: 301-594-3827
E-mail: andersonve@nigms.nih.gov
Biographical sketch

Bioorganic and Medicinal Chemistry

The design, synthesis and testing of novel molecules that modulate biochemical processes of potential clinical relevance. The synthesis and study of molecular probes, polymers, molecular assemblies and nanostructured materials of potential use in biological systems and medicine. Discovery and invention of mimics of macromolecular function and natural processes based on extrapolation from biological examples. Elucidation of inter- and intramolecular noncovalently controlled phenomena of chemical and biological relevance.

Miles A. Fabian, Ph.D.
Tel: 301-594-3827
E-mail: fabianm@nigms.nih.gov
Biographical sketch

Biotechnology

The development of potentially useful biochemical and chemical agents, and processes derived from living cells or their components. The development of engineering tools and technologies directed toward establishing in vivo means of producing useful biological materials (natural products, for example) or toward an expanded understanding of complex biological systems. Studies of the biosynthetic pathways for natural products including those used for communication in microbial communities and between the host and the microbial communities.

Miles A. Fabian, Ph.D.
Tel: 301-594-3827
E-mail: fabianm@nigms.nih.gov
Biographical sketch

Enzyme Catalysis and Regulation

The molecular basis of the catalytic and regulatory properties of enzymes, including those involved in the modification of macromolecules; biochemical intermediates produced in catalytic processes; the regulation, coordination or modification of primary and secondary metabolite production.

Oleg Barski, Ph.D.
Tel: 301-594-3827
E-mail: oleg.barski@nih.gov
Biographical sketch

Glycoconjugates

Structure, function and metabolism (synthesis, modification, degradation) of carbohydrate-containing macromolecules, especially where the emphasis is directed toward the carbohydrate portion of the molecule. The focus of investigations may range from glycoproteins and glycolipids to simple/complex polysaccharides of both prokaryotic and eukaryotic origin, and includes plant lectins.

Pamela Marino, Ph.D.
Tel: 301-594-3827
E-mail: marinop@nigms.nih.gov

Redox Biochemistry

Topics include structure and function of enzymes catalyzing oxidation-reduction reactions involving, e.g., flavin, heme, non-heme iron, copper and quinone cofactors, oxidases, oxygenases, hydroxylases, dehydrogenases, etc., except those directly involved in bioenergetics. Topics also include regulation of cellular redox balance, oxidative stress and detoxification of reactive oxygen species, nitrosative stress and protection from reactive nitrogen species.

Oleg Barski, Ph.D.
Tel: 301-594-3827
E-mail: oleg.barski@nih.gov
Biographical sketch

Synthesis and Methodology

Studies that advance the practice of organic synthesis through invention of new strategies for the construction of complex molecules; fundamental studies of chemical structure and reactivity; and the invention of new reagents, catalysts and reaction protocols. The development of enabling methodologies related to chemical diversity libraries (including library design, synthesis and validation) is included. Also includes studies on the isolation, purification and structural characterization of novel, non-macromolecular compounds from natural sources.

Robert Lees, Ph.D.
Tel: 301-594-3827
E-mail: leesro@mail.nih.gov
Biographical sketch


Pharmacological and Physiological Sciences

Anesthesia and Integrated Systems

Research on the systemic effects of anesthesia including: absorption, distribution, metabolism and biotransformation of local and general anesthetics, and adjuncts to anesthesia including muscle relaxants and analgesics; factors affecting distribution and interactions of anesthetics with other drugs, and ways in which anesthetic action is modified by different disease states. Includes research on the pharmacological effects of anesthetics on tissue, organ and multi-organ systems. Also includes studies on pain as it relates to anesthesia and the perioperative period. Studies on the cause, diagnosis, prevention or treatment of malignant hypothermia as it relates to anesthesia are also included.

Alison E. Cole, Ph.D.
Tel: 301-594-3827
E-mail: colea@nigms.nih.gov
Biographical sketch

Drug Disposition/Pharmacokinetics/Toxicology

The portfolio supports research that characterizes the biological processes involved in the disposition of therapeutic agents, models pharmacokinetic information for the development of programs to monitor drug therapy, and investigates the toxicological effects caused by therapeutic drugs. It includes research on Phase I and Phase II drug-metabolizing enzymes and drug transporters that mediate the absorption, distribution, metabolism and excretion of drugs and their metabolites (ADME). Studies to improve bioavailability of therapeutic molecules by altering interactions with drug transporters or drug-metabolizing enzymes are also supported. Quantitative analysis of pharmacokinetic parameters to develop mathematically based modeling programs to improve drug therapy is supported. Clinical toxicology studies include research into the adverse effects of therapeutic drugs that result from drug-drug or drug-protein interactions. The toxicology portfolio includes research that examines how induction or inhibition of drug-metabolizing enzymes, drug transporters or other proteins may result in adverse effects or that investigates the formation of unique metabolites that produce toxic effects in vivo. The portfolio also includes research on enzymes that metabolize arachidonic acid to biologically active or toxic agents.

Richard T. Okita, Ph.D.
Tel: 301-594-3827
E-mail: okitar@nigms.nih.gov
Biographical sketch

Ethical, Legal and Social Issues in Pharmacological and Physiological Sciences

These studies examine ethical, legal and social implications in the areas that the Pharmacological and Physiological Sciences Branch supports, primarily pharmacogenetics, clinical pharmacology, anesthesia and trauma and burn injury. It includes investigations related to the use of ethnically identifiable populations, stored tissues, informed consent, public databases and other related issues.

Rochelle M. Long, Ph.D.
Tel: 301-594-3827
E-mail: longr@nigms.nih.gov
Biographical sketch

Inflammation and Innate Immunity

Studies on cells, mediators and systems regulating onset, function and termination of the inflammatory and/or innate immune response. Studies may be molecular, biochemical and/or physiological and experiments may be conducted in vitro or in vivo. The use of model organisms is encouraged.

Sarah E. Dunsmore, Ph.D.
Tel: 301-594-3827
E-mail: dunsmores@nigms.nih.gov
Biographical sketch

Molecular Immunobiology

Basic cellular and molecular mechanisms, when cells of the immune system serve as advantageous experimental models. Areas include: signal transduction pathways; cellular aspects of differentiation; programmed cell death; cell adhesion; gene rearrangements, transcriptional regulation, exocytosis and endocytosis; protein transport.

Pamela Marino, Ph.D.
Tel: 301-594-3827
E-mail: marinop@nigms.nih.gov

Molecular Mechanisms of Anesthetics

Research on the molecular pharmacology and mechanisms of actions of anesthetics; includes interactions of general and local anesthetics with cellular membranes, receptors, ion channels and second-messenger systems. A wide range of experimental approaches may be employed, including but not limited to molecular biology, biochemistry, immunology, electrophysiology and biophysics. Also includes studies on molecular mechanisms of adverse actions and toxicity of anesthetics.

Alison E. Cole, Ph.D.
Tel: 301-594-3827
E-mail: colea@nigms.nih.gov
Biographical sketch

Pharmacogenomics

These studies address the contribution of genetic variation to individual differences in drug responses (pharmacogenetics and pharmacogenomics). The systems studied include mechanisms of drug metabolism and clearance, and the interactions of therapeutic drugs with their receptors and other biological targets. This includes the Pharmacogenomics Research Network and Knowledge Base, PharmGKB.

Rochelle M. Long, Ph.D.
Tel: 301-594-3827
E-mail: longr@nigms.nih.gov
Biographical sketch

Physiology

This section supports research in basic biological mechanisms of behavior and adaptation. This includes learning, information processing and communication systems; biological adaptation to environmental changes; electrophysiologic and endocrine correlates of behavior; and the physiology of sleep and stress.

Scott D. Somers, Ph.D.
Tel: 301-594-3827
E-mail: somerss@nigms.nih.gov
Biographical sketch

Receptors, Drug Targets and Signal Transduction

Studies of the molecular mechanisms of drug interactions with target receptors and the signaling pathways activated by drug interactions with target receptors. Studies may be molecular, biochemical, computational, biophysical and/or structural analysis of pharmacologically relevant targets. Includes studies of the biochemistry, structure, function and modulation of G proteins, accessory proteins interacting with G proteins such as the regulatory RGS proteins and arrestins, effector enzymes of signal transduction pathways such as adenylyl cyclase and small molecule mediators such as inositol trisphosphate and nitric oxide as well as pharmacological studies of ion channels and natural toxins that interact with ion channels. Other aspects of signal transduction research, for example, receptor binding theory.

Sarah E. Dunsmore, Ph.D.
Tel: 301-594-3827
E-mail: dunsmores@nigms.nih.gov
Biographical sketch

Sailaja Koduri, Ph.D.
Tel: 301-594-3900
E-mail: sailaja.koduri@nih.gov
Biographical sketch

Sepsis

Laboratory or clinical studies on sepsis, including septic shock or severe sepsis, predominantly from the perspective of the host and the response to a challenge rather than focusing on a presumptive causative microorganism. Studies will emphasize sepsis and not any disposing conditions such as traumatic injury.

Sarah E. Dunsmore, Ph.D.
Tel: 301-594-3827
E-mail: dunsmores@nigms.nih.gov
Biographical sketch

Trauma, Burn, and Peri-Operative Injury

This section supports basic and clinical investigations in such areas as physiology, biochemistry and immunology as they relate to the host response to traumatic, thermal or surgical injury, hemorrhagic shock and some complications of critical care medicine. The research is directed toward an improved understanding of the immediate as well as prolonged total body response to injury, including the biochemical and physiological changes induced by injury. Research supported in this section includes studies on the etiology of post-injury systemic inflammatory response syndrome, multiple organ dysfunction syndromes and other complications often seen in intensive or critical care units, and the mechanisms of immunosuppression and hypermetabolism following injury. In addition, the section encourages research on the treatment of post-traumatic infections, nutritional requirements of convalescing patients and the physiological basis of rehabilitation of injured patients.

Scott D. Somers, Ph.D.
Tel: 301-594-3827
E-mail: somerss@nigms.nih.gov
Biographical sketch

Wound Healing

This section supports basic and clinical investigations in such areas as physiology, biochemistry and immunology as they relate wound healing. The research is directed toward an improved understanding of the process of wound healing, the basic fundamental aspects of wound healing and the process of biological repair.

Scott D. Somers, Ph.D.
Tel: 301-594-3827
E-mail: somerss@nigms.nih.gov
Biographical sketch

Research Capacity Building

IDeA Centers of Biomedical Research Excellence (COBRE)

The goal of COBRE is to strengthen institutional biomedical research capabilities in IDeA-eligible states. COBRE supports three phases of infrastructure and faculty development in thematic, multidisciplinary centers.

COBRE Phase I

COBRE Phase I focus on the development of requisite research resources and infrastructure, and the provision of formal research mentoring and research project funding to junior investigators to facilitate their acquisition of preliminary data and successful competition for independent research grant support.

Yanping Liu, M.D., Ph.D.
Tel: 301-594-3900
E-mail: liuyanp@mail.nih.gov
Biographical sketch

COBRE Phase II

COBRE Phase II is intended to further strengthen existing COBRE centers through the support and enhancement of the growing research infrastructure and continuing the development and expansion of a critical mass of investigators with shared scientific interests.

Yanping Liu, M.D., Ph.D.
Tel: 301-594-3900
E-mail: liuyanp@mail.nih.gov
Biographical sketch

COBRE Phase III

COBRE Phase III primarily provides support for scientific and technical cores to become independent service research facilities in the institution, and to sustain the research environment developed in the first two phases.

J. Rafael Gorospé, M.D., Ph.D.
Tel: 301-594-3900
E-mail: gorospejr@mail.nih.gov
Biographical sketch

Science Education Partnership Awards (SEPA)

Science Education Partnership Award (SEPA) program supports educational activities, including interactive digital media resources, that complement or enhance the training of a workforce to meet the nation’s biomedical, behavioral and clinical research needs.

Tony Beck, Ph.D.
Tel: 301-435-0805
E-mail: beckl@mail.nih.gov

IDeA Networks of Biomedical Research Excellence (INBRE)

INBRE's goal is to enhance, extend and strengthen the research capabilities of biomedical and behavioral research faculty in IDeA states. The strategy is to build statewide, multidisciplinary research networks that expand the research opportunities and increase the number of competitive investigators in those states. INBRE supports institutional research and infrastructure development; research by faculty, postdoctoral scientists and students at participating institutions; and outreach to build science and technology knowledge in the states' workforces.

Krishan Arora, Ph.D.
Tel: 301-594-3900
E-mail: arorak@mail.nih.gov
Biographical sketch

IDeA Infrastructure for Clinical and Translational Research (IDeA-CTR)

IDeA-CTR encourages consortium applications from IDeA states to develop network infrastructure and capacity to conduct clinical and translational research focused on health concerns that affect medically underserved populations and/or that are prevalent in IDeA states. IDeA-CTR awards support mentoring and career development activities in clinical and translational research and facilitate collaboration among clinical researchers in IDeA and non-IDeA states.

J. Rafael Gorospé, M.D., Ph.D.
Tel: 301-594-3900
E-mail: gorospejr@mail.nih.gov
Biographical sketch

Native American Research Centers for Health (NARCH)

This initiative provides support for partnerships of American Indian or Alaska Native tribes or tribal-based organizations with institutions that conduct intensive, academic-level biomedical research. The intent is to develop opportunities for conducting research and research training responsive to the needs of Native American communities.

Sheila A. Caldwell, Ph.D.
Tel: 301-594-3900
E-mail: caldwells@nigms.nih.gov
Biographical sketch

SCORE Pilot Project Award

This award supports new investigators at institutions that have a historical mission focused on serving students from population groups underrepresented in the biomedical research workforce who wish to establish a line of research within the NIH mission but need preliminary data. Investigators who have received SCORE support previously may only apply for a SCORE pilot project award if they seek to change research fields and need preliminary data. The award is nonrenewable.

Hinda Zlotnik, Ph.D.
Tel: 301-594-3900
E-mail: zlotnikh@nigms.nih.gov
Biographical sketch

SCORE Research Advancement Award

This mechanism supports investigators at institutions that have a historical mission focused on serving students from population groups that have been shown to be underrepresented in the biomedical research workforce who seek to increase their research competitiveness in biomedical research fields, with the ultimate goal of making the transition to major non-SCORE support. This award may be renewed once.

Hinda Zlotnik, Ph.D.
Tel: 301-594-3900
E-mail: zlotnikh@nigms.nih.gov
Biographical sketch

SCORE Research Continuance Award

This mechanism supports investigators at institutions that have a historical mission focused on serving students from population groups underrepresented in the biomedical research workforce who still aim to improve their research competitiveness within an environment and circumstances that may require them to work at a less-intense pace than with a SCORE Research Advancement Award mechanism. The proposed projects must be of limited scope in a given biomedical field within the NIH mission. This award is renewable.

Hinda Zlotnik, Ph.D.
Tel: 301-594-3900
E-mail: zlotnikh@nigms.nih.gov
Biographical sketch

Training, Workforce Development, and Diversity

Undergraduate and Predoctoral Training

Bridges to the Baccalaureate (R25)

This initiative provides institutional support to partnerships between community colleges and colleges or universities that offer the baccalaureate degree to develop well-integrated developmental activities that will increase students preparation and skills as they advance academically in the pursuit and successful completion of the baccalaureate degree in biomedical sciences.

Mercedes Rubio, Ph.D.
Tel: 301-594-3900
E-mail: rubiome@mail.nih.gov
Biographical sketch

Patrick Brown, Ph.D.
Tel: 301-594-3900
E-mail: patrick.brown@nih.gov
Biographical sketch

Bridges to the Doctorate (R25)

This initiative provides institutional support to partnerships between institutions granting a terminal master’s degree and institutions that offer Ph.D. degrees to develop well-integrated developmental activities that will increase students’ preparation and skills as they advance academically in the pursuit and successful completion of the Ph.D. degree in biomedical sciences.

Patrick Brown, Ph.D.
Tel: 301-594-3900
E-mail: patrick.brown@nih.gov
Biographical sketch

Enhancing the Diversity of the NIH-Funded Workforce: Building Infrastructure Leading to Diversity (BUILD) (U54)

BUILD is a set of experimental training awards designed to implement and study innovative and effective approaches to engaging and retaining students from diverse backgrounds in biomedical research and preparing students to become future contributors to the NIH-funded research enterprise. BUILD is a part of the NIH Common Fund consortium Enhancing the Diversity of the NIH-Funded Workforce. Consortium contact: Alison Gammie.

Anissa J. Brown, Ph.D.
Tel: 301-594-3900
E-mail: anissa.brown@nih.gov
Biographical sketch

Richard Okita, Ph.D.
Tel: 301-594-3827
E-mail: okitar@nigms.nih.gov
Biographical sketch

Desirée Salazar, Ph.D.
Tel: 301-594-3900
E-mail: desiree.salazar@nih.gov
Biographical sketch

Initiative for Maximizing Student Development (IMSD) (R25)

Awards are for institutional programs that seek to increase the number of students from underrepresented groups in biomedical research who enter into and successfully complete Ph.D. degree programs in these fields. These awards are for institutions with a fully developed research infrastructure and full-time matriculated students from population groups that have been shown to be underrepresented in the biomedical research workforce. Support is limited to student development and training.

Veerasamy Ravichandran, Ph.D.
Tel: 301-451-9822
E-mail: ravichanr@nigms.nih.gov ravichanr@nigms.nih.gov
Biographical sketch

Sailaja Koduri, Ph.D.
Tel: 301-594-3900
E-mail: sailaja.koduri@nih.gov
Biographical sketch

MARC Undergraduate Student Training in Academic Research (U-STAR) Training Grants (T34)

This initiative provides support to 4-year colleges and universities with significant enrollment of students from population groups that have been shown to be underrepresented in the biomedical research workforce. These grants support research training in the biomedical sciences, including mathematics, for honors undergraduates in their junior and senior years, and are intended to prepare these students to compete successfully for entry into graduate programs leading to the Ph.D., M.D.-Ph.D. or other combined professional degree. Grants cover tuition, fees and stipends for trainees as well as trainee-related expenses.

Sailaja Koduri, Ph.D.
Tel: 301-594-3900
E-mail: sailaja.koduri@nih.gov
Biographical sketch

Luis Cubano, Ph.D.
Tel: 301-594-3900
E-mail: luis.cubano@nih.gov
Biographical sketch

Postbaccalaureate Research Education Program (PREP) (R25)

This initiative provides institutional support for the research training and education of recent baccalaureate graduates from population groups that have been shown to be underrepresented in the biomedical research workforce, who plan to pursue Ph.D. degrees. This research apprenticeship serves as an educational transition for recent baccalaureate graduates who will acquire essential academic credentials and research skills to make them more competitive for Ph.D. programs at highly selective institutions.

Michael Bender, Ph.D.
Tel: 301-594-0943
E-mail: mbender@nigms.nih.gov
Biographical sketch

Kenneth Gibbs, Ph.D.
Tel: 301-594-3901
E-mail: kenneth.gibbs@nih.gov
Biographical sketch

Research Initiative for Scientific Enhancement (RISE) (R25)

This initiative provides support to institutions with significant enrollment of students from populations groups that have been shown to be underrepresented in the biomedical sciences to implement a set of well-integrated developmental activities designed to strengthen students’ academic preparation, research training and professional skills critical for completion of the Ph.D. degree in the in biomedical sciences.

Luis Cubano, Ph.D.
Tel: 301-594-3900
E-mail: luis.cubano@nih.gov
Biographical sketch

Anissa J. Brown, Ph.D.
Tel: 301-594-3900
E-mail: anissa.brown@nih.gov
Biographical sketch

Ruth L. Kirschstein National Research Science Awards (NRSA) Institutional Research Training Grants (T32) - Predoctoral

All requests for general information about training grants should be directed to:
Shiva Singh, Ph.D.
Tel: 301-594-3900
E-mail: singhs@nigms.nih.gov
Biographical sketch

NIGMS staff members who manage specific training programs are listed below.

Behavioral-Biomedical Science Interface

Programs should provide graduate research training for students at the behavioral sciences-biomedical sciences interface. The goal of the program is to develop basic behavioral scientists with rigorous broad-based training in the biomedical sciences who are available to assume leadership roles related to the Nation’s biomedical research needs. These programs must provide an interdisciplinary research training experience and curriculum for predoctoral trainees that integrates both behavioral and biomedical perspectives, approaches and methodologies. Programs must include coursework, laboratory rotations and programmatic activities that reinforce training at this interface. Significant participation by faculty and leadership from both behavioral and biomedical science departments is required, as is co-mentoring of trainees by faculty from both components.

Shiva Singh, Ph.D.
Tel: 301-594-3900
E-mail: singhs@nigms.nih.gov
Biographical sketch

Bioinformatics and Computational Biology

Programs should train students in the background theory and biological application of information sciences (including computer science, statistics and mathematics) to problems relevant to biomedical research. Of particular interest are multiscale and large-scale problems in biology. Training should include the use of theory and computer application to the full spectrum of basic research in the biomedical sciences, including the analysis of molecular sequence and structure, molecular function, cellular function, physiology, genomics and genetics.

Stephen Marcus, Ph.D.
Tel: 301-451-6446
E-mail: marcusst@mail.nih.gov
Biographical sketch

Biostatistics

Provides support for predoctoral training that integrates biostatistical theory and evolving methodologies with basic biomedical research including, but not limited to, bioinformatics, genetics, molecular biology, cellular processes and physiology, as well as epidemiological and clinical studies. The goal is to ensure that a workforce of biostatisticians with a deep understanding of statistical theory and new methodologies is available to assume leadership roles related to the Nation’s biomedical research needs.

Kenneth Gibbs, Ph.D.
Tel: 301-594-3901
E-mail: kenneth.gibbs@nih.gov
Biographical sketch

Biotechnology

This training program supports the education of graduate students in the techniques and principles needed to pursue research in biotechnology. The education should be multidisciplinary, but provide a firm grounding in one or more of the fields that contribute to biotechnology, such as engineering, biophysics, biochemistry, genetics and cell biology. Faculty trainers and students participating in this program should be drawn from several departments but with a focus on engineering. The trainers should be conducting research relevant to the understanding and utilization of biological processes for biotechnological applications. These programs are expected to provide holistic training that should include, besides scientific theoretical and practical knowledge, communications skills, career development, and an understanding of regulatory, commercialization and IP issues in bringing a biotechnology product to the market. The program requires a mandatory 3 month internship in pharmaceutical or biotechnological industry. A close interaction between academic and industrial partners is strongly recommended.

Patrick Brown, Ph.D.
Tel: 301-594-3900
E-mail: patrick.brown@nih.gov
Biographical sketch

Cellular, Biochemical and Molecular Sciences

Programs should be of cross-disciplinary nature and involve in-depth study of biological problems at the level of the cellular and molecular sciences. The research training offered should encompass related disciplines, such as biochemistry, biophysics, chemistry, cell biology, developmental biology, genetics, immunology, microbiology, neurobiology and pathology.

Joe Gindhart, Ph.D.
Tel: 301-594-0828
E-mail: gindhartjg@nigms.nih.gov
Biographical sketch

Michael Bender, Ph.D.
Tel: 301-594-0943
E-mail: mbender@nigms.nih.gov
Biographical sketch

Chemistry-Biology Interface

Training programs in this area should provide significant biological training to students receiving in-depth training in a chemical discipline and provide significant training in chemistry to students being trained in depth in the biological sciences. CBI programs should have a focus on the use of synthetic and mechanistic chemistry as approaches to studying biological problems. Programs will consist primarily of faculty drawn from departments of chemistry, medicinal chemistry and/or pharmaceutical chemistry and faculty from the biological disciplines, such as biochemistry, molecular biology and cell biology. Students trained at the chemistry-biology interface should be well-grounded in a core discipline and sufficiently well-trained in complementary fields to allow them to work effectively in a multidisciplinary team.

Miles A. Fabian, Ph.D.
Tel: 301-594-3827
E-mail: fabianm@nigms.nih.gov
Biographical sketch

Genetics

Programs should emphasize broad training in the principles and mechanisms of genetics and related sciences. Training in a variety of areas such as classical genetics, molecular genetics, population genetics, and developmental genetics should be included. Programs should also include training and research opportunities in related disciplines such as biochemistry, cell biology and statistics.

Susan Haynes, Ph.D.
Tel: 301-594-0943
E-mail: hayness@nigms.nih.gov
Biographical sketch

Medical Scientist Training Program (MSTP)

The Medical Scientist Training Program (MSTP) supports the training of students who are motivated to undertake a career in biomedical research and academic medicine in an integrated program of scientific and medical study leading to the combined M.D.-Ph.D. degree. The program's goal is to prepare its graduates to function independently in both basic research and clinical investigations.

Stefan Maas, Ph.D.
Tel: 301-594-0943
E-mail: maassw@nigms.nih.gov
Biographical sketch

Molecular Biophysics

Training in this area should be multidisciplinary and focus on the application of physics, mathematics and chemistry to the problems of biological structure, primarily at the molecular level. These programs should bring together faculty from departments such as chemistry, physics and engineering who have an interest in biologically related research with faculty in biological science departments whose orientation is the application of physical methods and concepts to biological systems.

Paula Flicker, Ph.D.
Tel: 301-594-0828
E-mail: flickerp@nigms.nih.gov
Biographical sketch

Molecular Medicine

Training in molecular medicine is intended to combine rigorous didactic training in the basic biomedical sciences with exposure to concepts and knowledge underlying the molecular basis of disease. In addition to training in the core concepts of molecular biology, cell biology and biochemistry, trainees in molecular medicine should have specialized required courses such as pathophysiology and molecular pathogenesis, and program activities, such as seminar series or journal clubs, that provide students with a better understanding of disease mechanisms. Examples of other features that would enhance training in molecular medicine could include dual mentors in basic and clinical science, and exposure to the concepts of medicine through participation in grand rounds. As with all NIGMS training programs, training faculty should be broadly drawn from multiple departments and disciplines and thesis research topics should similarly reflect a broad range of interdisciplinary opportunities in the basic biomedical sciences. The goal is to train a cadre of scientists prepared to work at the interface of basic biomedical science and clinical research, an area sometimes referred to as translational research. This training opportunity should be primarily designed for Ph.D. candidates; M.D. and M.D./Ph.D. doctoral candidates may be interested in such a program and could participate, but should not be the ones for whom a training program in molecular medicine is designed and should not be appointed as trainees to the training grant. A training program in Molecular Medicine should attract a new and distinct pool of students, and the training should clearly be differentiated from that offered by other training programs at the Institution.

Alison E. Cole, Ph.D.
Tel: 301-594-3827
E-mail: colea@nigms.nih.gov
Biographical sketch

Pharmacological Sciences

Training programs in this area should be multidisciplinary and emphasize the acquisition of competence in the broad field of pharmacological sciences. Individuals should receive training that will enable them to conduct research on the biological phenomena and related chemical and molecular processes involved in the actions of therapeutic drugs and their metabolites. Thesis research opportunities should be available with faculty members in a variety of disciplines, such as biochemistry, chemistry, genetics, toxicology, medicinal chemistry, physiology and neurosciences, as well as pharmacology.

Richard T. Okita, Ph.D.
Tel: 301-594-3827
E-mail: okitar@nigms.nih.gov
Biographical sketch

Systems and Integrative Biology

Training in this area should be directed toward building the broad research competence required to investigate integrative, regulatory and developmental processes of higher organisms and their functional components. The training program should bring together varied resources, approaches and thesis research opportunities with faculty mentors of such disciplines/departments as physiology, biomedical engineering, the neurosciences, biochemistry and cell and developmental biology. Graduates of the program should be well-versed in quantitative, integrative and systems approaches to biology.

Zhongzhen Nie, Ph.D.
Tel: 301-594-0828
E-mail: niezhong@nigms.nih.gov
Biographical sketch

Ruth L. Kirschstein National Research Service Awards (NRSA) Individual Predoctoral Fellowships (F30 and F31)

Awards are for individuals who seek advanced predoctoral research training in basic biomedical sciences relevant to the NIGMS mission. These fellowships promote fundamental, interdisciplinary and innovative research training and career development leading to independent scientists who are well prepared to address the nation's biomedical research needs.

All requests for general information about predoctoral fellowships should be directed initially to:
Shiva Singh, Ph.D.
Tel: 301-594-3900
E-mail: singhs@nigms.nih.gov
Biographical sketch

For information specific to the different kinds of fellowships listed below, contact the indicated staff member.

Predoctoral M.D./Ph.D. or Other Dual-Doctoral Degree Fellowships (F30)

These awards are designed to enhance the integrated research and clinical training of promising predoctoral students, who are matriculated in a combined M.D.-Ph.D. or other dual-doctoral degree training program (e.g. D.O.-Ph.D., D.D.S.-Ph.D., Au.D.-Ph.D., D.V.M.-Ph.D), and who intend careers as physician-scientists or other clinician-scientists. The fellowship experience is expected to clearly enhance the individuals’ potential to develop into productive, independent physician-scientists or other clinician-scientists.

Kenneth Gibbs, Ph.D.
Tel: 301-594-3901
E-mail: kenneth.gibbs@nih.gov
Biographical sketch

Predoctoral Fellowships for Ph.D. Degree Students (Parent F31)

These awards are designed to enable promising predoctoral students to obtain individualized, mentored research training in basic biomedical sciences from outstanding faculty sponsors while conducting dissertation research in scientific health-related fields relevant to the NIGMS mission. The fellowship experience is expected to clearly enhance the individuals' potential to develop into productive, independent scientists who are well prepared to address the nation's biomedical research needs

Biomedical Technology, Bioinformatics, and Computational Biology

Veerasamy Ravichandran, Ph.D.
Tel: 301-451-9822
E-mail: veerasamy.ravichandra@nih.gov
Biographical sketch

Cell Biology and Biophysics

Ward Smith, Ph.D.
Tel: 301-594-0828
E-mail: smithwar@nigms.nih.gov
Biographical sketch

Genetics and Developmental Biology

Darren Sledjeski, Ph.D.
Tel: 301-594-0943
E-mail: darren.sledjeski@nih.gov
Biographical sketch

Pharmacology, Physiology, and Biological Chemistry

Oleg Barski, Ph.D.
Tel: 301-496-1511
E-mail: oleg.barski@nih.gov
Biographical sketch

Predoctoral Fellowships to Promote Diversity in Health-Related Research (F31)

This NIH-wide program funds predoctoral fellowships for students (enrolled in Ph.D. or combined degree program) from population groups that have been shown to be underrepresented in the biomedical research workforce, preparing them to enter research careers in biomedical sciences.

Patrick Brown, Ph.D.
Tel: 301-594-3900
E-mail: patrick.brown@nih.gov
Biographical sketch

Anissa J. Brown, Ph.D.
Tel: 301-594-3900
E-mail: anissa.brown@nih.gov
Biographical sketch

Postdoctoral Training

Career Development Awards

Clinical Career Development Awards (K08/K23)

These awards support the development of outstanding academic physician-scientists in the areas of anesthesiology, clinical pharmacology, innate immunity, inflammation, sepsis, and trauma and burn injury. They provide support for a period of 3 to 5 years of supervised research and study to clinically trained professionals who have the commitment and potential to develop into productive, independent investigators.

Anesthesiology

Alison E. Cole, Ph.D.
Tel: 301-594-3827
E-mail: colea@nigms.nih.gov
Biographical sketch

Clinical Pharmacology

Rochelle M. Long, Ph.D.
Tel: 301-594-3827
E-mail: longr@nigms.nih.gov
Biographical sketch

Innate Immunity and Inflammation

Sarah E. Dunsmore, Ph.D.
Tel: 301-594-3827
E-mail: dunsmores@nigms.nih.gov
Biographical sketch

Sepsis

Sarah E. Dunsmore, Ph.D.
Tel: 301-594-3827
E-mail: dunsmores@nigms.nih.gov
Biographical sketch

Trauma and Burn Injury Research

Scott D. Somers, Ph.D.
Tel: 301-594-3827
E-mail: somerss@nigms.nih.gov
Biographical sketch

Mentored Quantitative Research Career Awards (K25)

These awards support the career development of quantitatively trained investigators from the postdoctoral level to the senior faculty level who make a commitment to basic or clinical biomedicine, bioengineering or bioimaging research that is relevant to the NIH mission.

Stephen Marcus, Ph.D.
Tel: 301-451-6446
E-mail: marcusst@nigms.nih.gov
Biographical sketch

Pathway to Independence Awards (K99/R00)

This program provides support for both mentored and independent research from the same award. The award provides up to 5 years of support consisting of two phases: the initial phase (K99) provides 1-2 years of mentored support to highly promising, postdoctoral research scientists, followed by up to 3 years of independent support (R00) contingent on the scientist securing an independent research position. Applications are accepted for research and training aligned with the NIGMS research priorities. NIGMS encourages postdoctoral trainees to apply by their third year of postdoctoral training.

Requests for general information about individual postdoctoral fellowships should be directed to:
Michael Sesma, Ph.D.
Tel: 301-594-2722
E-mail: msesma@nigms.nih.gov
Biographical sketch

For information specific to the training program areas listed below, contact the indicated staff member.

Stephen Marcus, Ph.D., Division of Biomedical Technology, Bioinformatics, and Computational Biology
Tel: 301-451-6446
E-mail: marcusst@mail.nih.gov
Biographical sketch

Paula Flicker, Ph.D., Division of Cell Biology and Biophysics
Tel: 301-594-0828
E-mail: flickerp@nigms.nih.gov
Biographical sketch

Michael Sesma, Ph.D., Division of Genetics and Developmental Biology
Tel: 301-594-0943
E-mail: msesma@nigms.nih.gov
Biographical sketch

Oleg Barski, Ph.D., Division of Pharmacology, Physiology, and Biological Chemistry
Tel: 301-594-3827
E-mail: oleg.barski@nih.gov
Biographical sketch

Enhancing the Diversity of the NIH-Funded Workforce: National Research Mentoring Network (NRMN) (U54)

NRMN is developing a national network of motivated and skilled mentors from various disciplines linked to mentees across the country–both from BUILD institutions and elsewhere–for individuals at the undergraduate to early career faculty levels and spanning biomedical disciplines relevant to the NIH mission. It is also developing best practices and training opportunities for mentors, as well as networking and professional development opportunities for mentees. NRMN is a part of the NIH Common Fund consortium Enhancing the Diversity of the NIH-Funded Workforce. Consortium contact: Alison Gammie.

Mercedes Rubio, Ph.D.
Tel: 301-594-3900
E-mail: rubiome@nigms.nih.gov
Biographical sketch

Enhancing the Diversity of the NIH-Funded Workforce: Coordination and Evaluation Center (CEC) (U54)

The CEC coordinates activities and will evaluate the efficacy of the training and mentoring approaches developed by BUILD and NRMN awardees. These findings will have implications for recruiting, training and mentoring of diverse groups nationwide, and the CEC will disseminate effective approaches to the broader research and mentoring communities. CEC is a part of the NIH Common Fund consortium Enhancing the Diversity of the NIH-Funded Workforce. Consortium contact: Alison Gammie.

Michael Sesma, Ph.D.
Tel: 301-594-2772
E-mail: msesma@nigms.nih.gov
Biographical sketch

Individual Postdoctoral Fellowships (F32) and Senior Fellowships (F33)

The F32 fellowship is for individuals who seek postdoctoral research training in areas related to the scientific programs of the institute. The senior fellowships (F33) are for established independent investigators.

Requests for general information about individual postdoctoral fellowships should be directed to:
Michael Sesma, Ph.D.
Tel: 301-594-2772
E-mail: msesma@nigms.nih.gov
Biographical sketch

For postdoctoral fellowship information specific to the program areas listed below, contact the indicated staff member:

Biochemistry and Bio-Related Chemistry

Oleg Barski, Ph.D.
Tel: 301-594-3827
E-mail: oleg.barski@nih.gov
Biographical sketch

Robert Lees, Ph.D.
Tel: 301-594-3827
E-mail: leesro@nigms.nih.gov
Biographical sketch

Bioinformatics and Computational Biology

Veerasamy Ravichandran, Ph.D.
Tel: 301-451-9822
E-mail: ravichanr@nigms.nih.gov
Biographical sketch

Biotechnology

Assigned to all postdoctoral areas/disciplines

Cell Biology

Ward Smith, Ph.D.
Tel: 301-594-0828
E-mail: smithwar@nigms.nih.gov
Biographical sketch

Genetics and Developmental Biology

Applicant's last name beginning A-F contact Dr. Melillo; Applicant's last name beginning G-N contact Dr. Maas; Applicant’s last name beginning O-Z contact Dr. Willis.

Amanda Melillo, Ph.D.
Tel: 301-594-0943
E-mail: amanda.melillo@nih.gov
Biographical sketch

Stefan Maas, Ph.D.
Tel: 301-594-0943
E-mail: maassw@nigms.nih.gov
Biographical sketch

Kristine Willis, Ph.D.
Tel: 301-594-0943
E-mail: kristine.willis@nih.gov
Biographical sketch

Molecular Biophysics

Paula Flicker, Ph.D.
Tel: 301-594-0828
E-mail: flickerp@nigms.nih.gov
Biographical sketch

Pharmacological Sciences, Anesthesiology and Clinical Pharmacology

Oleg Barski, Ph.D.
Tel: 301-594-3827
E-mail: oleg.barski@nih.gov
Biographical sketch

Physiology

Oleg Barski, Ph.D.
Tel: 301-594-3827
E-mail: oleg.barski@nih.gov
Biographical sketch

Robert Lees, Ph.D.
Tel: 301-594-3827
E-mail: leesro@nigms.nih.gov
Biographical sketch

Quantitative Biology

Assigned to all postdoctoral areas/disciplines

Trauma, Burn and Peri-Operative Injury

Oleg Barski, Ph.D.
Tel: 301-594-3827
E-mail: oleg.barski@nih.gov
Biographical sketch

Institutional Research and Academic Career Development Award (IRACDA)

These awards provide institutional support to partnerships between a research-intensive university and one or more partner institutions that have a historical mission and a demonstrated commitment to providing training, encouragement and assistance to students from population groups underrepresented in the biomedical research workforce. The grant supports postdoctoral trainees who are engaged in cutting-edge research at the research-intensive university and who also participate in teaching at a partner institution, thus helping improve the research environment and also providing diversity in courses available to students at these institutions.

Jessica Faupel-Badger, Ph.D.
Tel: 301-594-3827
E-mail: badgerje@mail.nih.gov
Biographical sketch

Innovative Programs to Enhance Research Training (IPERT)

The IPERT supports creative and innovative research educational activities designed to complement and/or enhance the training of a workforce to meet the nation’s biomedical research needs. Each IPERT program must address the NIGMS goals of creating a highly skilled and diverse biomedical workforce. The programs can be designed to support stages of research career development from the undergraduate to the faculty level and must be ancillary or complementary to those research training and research education programs in which they currently participate, regardless of the source of support. While the balance of activities in a single application may vary, an IPERT application must effectively integrate three core elements: short-courses/workshops for skills development; mentoring; and outreach. This opportunity may be appropriate for research conferences, program-related workshops and activities, and educational projects previously supported by the expired MARC Ancillary Training Activities (T36) FOA.

Michael Sesma, Ph.D.
Tel: 301-594-2772
E-mail: msesma@nigms.nih.gov
Biographical sketch

Ruth L. Kirschstein National Research Service Awards (NRSA) Institutional Research Training Grant (T32) - Postdoctoral

Requests for general information about institutional postdoctoral fellowships should be directed to:
Alison E. Cole, Ph.D.
Tel: 301-594-3827
E-mail: colea@nigms.nih.gov
Biographical sketch

NIGMS staff members who manage specific training programs are listed below.

Anesthesiology

Programs should provide multidisciplinary research training to help develop individuals with the skills and expertise to explore problems relevant to anesthesiology, including the fundamental mechanisms of anesthetic action. The goal is to provide rigorous postdoctoral research training with an emphasis on hypothesis-driven laboratory or clinical research. Trainees, most of whom would hold the M.D. degree, will be expected to spend at least 2 years in the training program and should have the opportunity to acquire fundamental knowledge and research techniques in such disciplines as biochemistry, biophysics, cell biology, molecular biology, neurobiology, pharmacology or physiology. For trainees with the Ph.D. degree, the research and training should be specifically designed to promote a research career addressing problems in anesthesiology.

Alison E. Cole, Ph.D.
Tel: 301-594-3827
E-mail: colea@nigms.nih.gov
Biographical sketch

Clinical Pharmacology

Individuals in these training programs should receive experience in the methodology and in the conduct of clinical and basic research to qualify them to investigate the effects and mechanisms of drug actions in humans. Trainees, who would usually have the M.D. degree, should have the opportunity to acquire fundamental scientific knowledge and learn research techniques in areas such as basic pharmacology, biochemistry, physiology, biostatistics and other biomedical subdisciplines.

Richard T. Okita, Ph.D.
Tel: 301-594-3827
E-mail: okitar@nigms.nih.gov
Biographical sketch

Medical Genetics

Training programs should provide advances and specialized research training in the principles of genetics with the goal of understanding human genetic disorders. Trainees should be drawn from diverse backgrounds and should be offered opportunities for conducting research with faculty who represent a variety of approaches to genetics ranging from molecular genetics to human population genetics. For holders of the M.D. or other professional degrees, the program should provide training and research opportunities in areas of basic genetics. This training should build on, and complement, the trainee's clinical background. For holders of the Ph.D. degree, the research and training should emphasize the application of the trainee's basic genetics background to problems in human and medical genetics.

Susan Haynes, Ph.D.
Tel: 301-594-0943
E-mail: hayness@nigms.nih.gov
Biographical sketch

Trauma, Burn, and Peri-Operative Injury

Support for multidisciplinary research training is offered to individuals holding the M.D. or Ph.D. degree who seek to improve the understanding of the body's systemic responses to major injury and to foster the more rapid application of this knowledge to the treatment of trauma and burn-injured victims and/or critically ill patients. The supervisory staff of the training program should include trauma surgeons, burn specialists and critical care specialists as well as basic scientists. Trainees, most of whom would hold the M.D. degree, will be expected to spend at least 2 years in the training program and to apply such basic disciplines as physiology, biochemistry, immunology, microbiology, cell biology, molecular biology, biomedical engineering or behavioral sciences to the study of injury and/or critical illness.

Scott D. Somers, Ph.D.
Tel: 301-594-3827
E-mail: somerss@nigms.nih.gov
Biographical sketch

Research Supplements to Promote Diversity in Health-Related Research and Supplements to Promote Reentry into Biomedical and Behavioral Research Careers

This NIH-wide program provides supplemental funds to principal investigators holding NIGMS research grants, to improve the diversity of the research workforce by supporting and recruiting students and postdoctoral fellows from underrepresented racial and ethnic groups, individuals with disabilities and individuals from economically or educationally disadvantaged backgrounds that have inhibited their ability to pursue a career in health-related research.

Mercedes Rubio, Ph.D.
Tel: 301-594-3900
E-mail: rubiome@mail.nih.gov
Biographical sketch



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This page last reviewed on September 21, 2016